Knotty Bodies is a game that resides in the Dexatorium and is a popular game in the world of Dexter's Laboratory. In the game players stand in a white room with red, yellow, green and blue spots that the walls/ceiling/floor. The Computer tells what specific body part should be on what spot (like putting a right knee on a blue dot). The player who can not reach for a spot loses. The advanced computerized version of this game first appeared in "Game for a Game" as one of the many challenges between Dee Dee and Dexter in the Dexatorium. The regular home version would later appear again in Ego Trip where Mom and Dad were seen playing it.
- It is a parody of the game Twister.