|First Appearance||The Big Sister|
|Voiced By||Kath Soucie|
When a giant Dee Dee was causing havoc down town, she began to make the news with many innocents, including the president, begging for help. Dexter sees the news and realizes that this could be his chance to become a famous hero by getting rid of Dee Dee. He then fantasizes about the scantily clad Ms. Physics personally thanking him by giving him a kiss on the cheek.
- Her name is a reference to the Miss Universe pageant.