|First Appearance||Dee Dee and the Man|
The Replacement Sisters were random girls and actresses that auditioned to be Dee Dee's replacement after Dexter had enough of Dee Dee's idiocy in the episode Dee-Dee and the Man. He ultimately decides on Candi, an attractve blonde only for her to quit when she realises its not a tv show but a real lab.
- A dark-haired girl in a green dress who likes peace and quiet as much as Dexter
- A curvy young brunette who has a criminal record
- A red-head girl in a red dress with a Southern accent
- A drooling baby
- Spastic Sister, a perky nun
- A blonde girl
- A brunette girl in overalls
- A geeky bucktoothed girl
- Candi, a professional actress
The other participants:
- The red haired girl resembles the character Annie from the titular musical.